月归档:六月 2011

Trophoblastic proliferation 滋养层增生

In partial moles, some villi appear normal, whereas others are swollen, avascular, and grape-like (though not as large as a complete mole). There is minimal trophoblastic proliferation. In fact, most placentas in cases of triploidy do not have grossly recognizable … 继续阅读

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Scattered grape-like villi 分散绒毛葡萄

This is a partial hydatidiform mole. Note that there are only scattered grape-like villi. Such a partial mole occurs when an ovum is fertilized by two haploid sets of paternal chromosomes. This may occur with dispermy when two sperms fertilize … 继续阅读

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Trophoblastic disease 滋养层疾病

The pathologist determines the histologic diagnosis of the trophoblastic disease; most importantly, if choriocarcinoma is present. In this complete hydatidiform mole shown here there is atypical trophoblastic proliferation, but chorionic villi are still present. The patient is then followed with … 继续阅读

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Gestational trophoblastic disease 妊娠滋养层疾病

One form of gestational trophoblastic disease, a molar pregnancy, results from abnormal fertilization of the ovum. A complete hydatidiform mole, shown here, occurs when the ovum is lacking a maternal complement of chromosomes and is fertilized by a haploid sperm, … 继续阅读

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Hydrops of the placenta 胎儿积水

Hydrops of the placenta, as shown here, almost always accompanies fetal hydrops. Causes for fetal hydrops may include fetal anemia, fetal cardiac disease, congenital anomalies, and congenital infections, but there are a multitude of potential causes for hydrops.

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Congenital cytomegalovirus infection先天性巨细胞病毒感染

Placental villitis seen here is accompanied by a couple of enlarged cells with mauve intranuclear inclusions typical for congenital cytomegalovirus infection. Such inclusions may be difficult to find, and the inflammation can be focal, with lymphocytes, plasma cells, and occasional … 继续阅读

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Congenital cytomegalovirus(CMV) infection 先天性巨细胞病毒(CMV)感染

Placental villitis at the bottom is seen in conjunction with hydropic change at the top in this placenta with congenital cytomegalovirus (CMV) infection. Both of these microscopic changes can occur together. Congenital infection is a common cause for hydrops fetalis.

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,Microabscess 微脓疡

Placental villitis is shown here with a small microabscess containing mostly neutrophils in a case of congenital infection with Listeria monocytogenes. Listeriosis is generally not life-threatening to the mother, but is potentially a cause for fetal demise.

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Acute inflammation 急性炎症

Premature and/or prolonged rupture of fetal membranes (PROM) increases the risk for intrauterine infection, because bacteria can pass into the normally sealed amniotic cavity. This leads to acute inflammation as seen here as an acute chorioamnionitis within the fetal membranes. … 继续阅读

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Tan-yellow nodules 棕黄色结节

On the fetal surface here are seen several tan-yellow nodules. This is amnion nodosum, which typically occurs in association with long-standing oligohydramnios. [Image contributed by John Nicholls, MD, Hong Kong University]

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