月归档:六月 2013

Prostate__CysticAtrophy 前列腺囊性萎缩

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Prostate_Atrophy_SimpleAtrophya.前列腺单纯性萎缩

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书法79

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Prostate_Atrophy_Sclerotica硬化性前列腺萎缩

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Partial Atrophy部分萎缩

Partial atrophy is one of the most challenging mimics of prostate cancer. The focus shown here still retains lobular configuration. The glands are pale and lack the basophilic appearance typical of a fully developed focus of atrophy. Nuclear enlargement and … 继续阅读

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书法78

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Atrophy – 34bE12 Immunostain前列腺萎缩- 34 be12应用

The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic variant of prostatic adenocarcinoma (no basal cell layer).

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Atrophic variant of Prostatic Adenocarcinoma前列腺腺癌的萎缩变

Notwithstanding the superficial resemblance to atrophy, the glands in atrophic variant of prostatic adenocarcinoma show an infiltrative growth pattern. The nuclear features typical of malignancy are present (nuclear enlargement and prominent nucleoli). In difficult cases, HMWCK immunostains can be helpful.

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Atrophy – Nuclear Features前列腺萎缩核的特征

The atrophic glands have scant cytoplasm and hyperchromatic nuclei with occasional punctate nucleoli. The basal cell layer is fragmented but still present as confirmed by high molecular weight cytokeratin immunostain (next slide).

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书法77

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